Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma.

@article{Yoshizaki2001ExpressionOT,
  title={Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma.},
  author={Tomokazu Yoshizaki and Yuichiro Maruyama and Hiroshi Sato and Masayuki Furukawa},
  journal={International journal of cancer},
  year={2001},
  volume={95 1},
  pages={
          44-50
        }
}
Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential for cell-mediated activation of MMP-2 and thus, the contribution of TIMP-2 to tumor invasion has remained controversial. This study was designed to analyze the role of TIMP-2 for… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 65 CITATIONS, ESTIMATED 49% COVERAGE

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations