Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer.

@article{Mino2007ExpressionOT,
  title={Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer.},
  author={Nobuya Mino and Kazumasa Takenaka and Makoto Sonobe and Ryo Miyahara and Kazuhiro Yanagihara and Yosuke Otake and Hiromi Wada and Fumihiro Tanaka},
  journal={Journal of surgical oncology},
  year={2007},
  volume={95 3},
  pages={250-7}
}
BACKGROUND AND OBJECTIVES Tissue inhibitor of metalloproteinase-3 (TIMP-3) inhibits the activity of metalloproteinases that play important roles in development and progression of malignant tumors. We conducted a retrospective study of TIMP-3 expression in resected non-small cell lung cancer (NSCLC). METHODS TIMP-3 expression was examined immunohistochemically in primary tumor specimens from 143 patients who underwent complete resection for NSCLC. Correlations between TIMP-3 expression grade… CONTINUE READING