Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis.

@article{Johnson2005ExpressionOT,
  title={Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis.},
  author={Adam H Johnson and Henry F. Frierson and Alexander Zaika and Steven M. Powell and James K. Roche and Sheila Eileen Crowe and Christopher A. Moskaluk and Wa'el M El-Rifai},
  journal={The American journal of pathology},
  year={2005},
  volume={167 2},
  pages={577-84}
}
Trefoil factor-1 (Tff1) expression is remarkably down-regulated in nearly all human gastric cancers. Therefore, we used the Tff1 knockout mouse model to detect molecular changes in preneoplastic gastric dysplasia. Oligonucleotide microarray gene expression analysis of gastric dysplasia of Tff1-/- mice was compared to that of normal gastric mucosa of wild-type mice. The genes most overexpressed in Tff1-/- mice included claudin-7 (CLDN7), early growth response-1 (EGR1), and epithelial membrane… CONTINUE READING
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