Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma.

@article{Sakaguchi2008ExpressionOT,
  title={Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma.},
  author={Takanori Sakaguchi and Shohachi Suzuki and Hiroyuki Higashi and Keisuke Inaba and Satoshi Nakamura and S. El Baba and Tomoyuki Kato and Hiroyuki Konno},
  journal={The Journal of surgical research},
  year={2008},
  volume={147 1},
  pages={
          123-31
        }
}
BACKGROUND An increase of leaky vasculature is vital for the growth and metastasis of hepatocellular carcinoma (HCC). The paracellular permeability-regulating proteins in tumor vessels and adjacent sinusoids have not been studied in HCC patients. METHODS Expression of an endothelial tight junction protein claudin-5 (CL-5) and a standard endothelial marker CD34 were immunohistochemically examined in resected specimens from 51 HCC cases. The relationship between hepatitic or fibrotic grade and… CONTINUE READING
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