Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells.

  title={Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells.},
  author={Masumi Inoue and Masato Tawata and Norihiko Yokomori and Toyoshi Endo and Toshimasa Onaya},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={8 11},
The expression of thyrotropin receptor (TSH-R) on various cells derived from bone, including osteoblast-like rat osteosarcoma cells (UMR106 cells), was investigated. TSH receptor mRNA was detected in UMR106 cells by Northern blot analysis. 125I-labeled TSH binding analysis revealed specific high- and low-affinity binding sites (association constants of 5.6 x 10(9) M(-1) and 3.0 x 10(7) M(-1), respectively) on UMR106 cells. Recombinant TSH, but not recombinant human chorionic gonadotropin… CONTINUE READING


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