Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue

@article{Feliciello1993ExpressionOT,
  title={Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue},
  author={Antonio Feliciello and Ilaria Ciullo and Gf. Fenzi and Giulio Bonavolont{\`a} and Enrico Vittorio Avvedimento},
  journal={The Lancet},
  year={1993},
  volume={342},
  pages={337-338}
}
It is not clear whether the ophthalmopathy present in Graves' disease is related to autoimmune reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found. We have shown, by polymerase chain reaction amplification of specific cDNA, that mature TSH-R mRNA is expressed in the retro… CONTINUE READING
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