Expression of thyroid hormone transporters during critical illness.

@article{Mebis2009ExpressionOT,
  title={Expression of thyroid hormone transporters during critical illness.},
  author={Liese Mebis and Deborah Paletta and Yves Debaveye and Bjoern Ellger and Lies Langouche and Andr{\'e} D’Hoore and Veerle M. Darras and Theo J. Visser and Greet Van den Berghe},
  journal={European journal of endocrinology},
  year={2009},
  volume={161 2},
  pages={
          243-50
        }
}
OBJECTIVE Prolonged critically ill patients have low circulating thyroid hormone (TH) levels without a rise in TSH, a condition labeled 'the low tri-iodothyronine (T(3)) syndrome'. Currently, it is not clear whether this represents an adaptive response. We examined the role of TH transporters monocarboxylate transporter 8 (MCT8, also known as SLC16A2) and MCT10 in the pathogenesis of the low T(3) syndrome in prolonged critical illness. METHODS A clinical observational study in critically ill… CONTINUE READING

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