Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer

@article{Nakao2010ExpressionOT,
  title={Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer},
  author={Toshihiro Nakao and Nobuhiro Kurita and Masato Komatsu and Kozo Yoshikawa and T Hisato Iwata and Toru Utsunomiya and Mitsuo Shimada},
  journal={International Journal of Clinical Oncology},
  year={2010},
  volume={16},
  pages={145-152}
}
It has been suggested that thrombospondin-1 (TSP-1) plays a role in angiogenesis in many cancers. In addition, TSP-1 has been shown to suppress tumor growth by activating transforming growth factor-β (TGF-β). Recent studies have shown that Ski protein suppresses TGF-β signaling. The aim of this study was to investigate the role of TSP-1 and Ski expression in advanced gastric cancer. Sixty-five recurrent patients who underwent resection of advanced gastric cancer (n = 62) or who had unresectable… CONTINUE READING