Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development.

@article{Chen1999ExpressionOT,
  title={Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development.},
  author={Shihao Chen and Sihong Zhou and Mohan Lai Sarkar and Andrew M. Spence and Harry Schachter},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 1},
  pages={288-97}
}
UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase I (GnT I) is a key enzyme in the synthesis of Asn-linked complex and hybrid glycans. Studies on mice with a null mutation in the GnT I gene have indicated that N-glycans play critical roles in mammalian morphogenesis. This paper presents studies on N-glycans during the development of the nematode Caenorhabditis elegans. We have cloned cDNAs for three predicted C. elegans genes homologous to mammalian GnT I… CONTINUE READING

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