Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.

  title={Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.},
  author={Matthew C. Cook and Allan B Gould and Nigel Brand and Jennifer Davies and Pamela J. Strutt and Rita Shaknovich and Jonathan M. Licht and Samuel Waxman and Zhu Chen and S. Gluecksohn-waelsch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 6},
To investigate the potential biological role(s) of the PLZF gene, discovered as a fusion with the RARA locus in a patient with acute promyelocytic leukemia harboring a t(11;17) chromosomal translocation, we have isolated its murine homologue (mPLZF) and studied its patterns of developmental expression. The levels of mPLZF mRNAs increased perinatally in the liver, heart, and kidney, but with the exception of the heart, they were either absent or very low in the adult tissues. In situ analysis of… CONTINUE READING
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