Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

@article{Berkman1993ExpressionOT,
  title={Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.},
  author={R A Berkman and Marsha J. Merrill and William C. Reinhold and William T Monacci and Anjana Saxena and William C. Clark and James T. Robertson and Iqbal Unnisa Ali and Edward H. Oldfield},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 1},
  pages={153-9}
}
Expression of the vascular permeability factor/vascular endothelial growth factor (VEGPF) gene was investigated in human central nervous system (CNS) neoplasms and normal brain. Adsorption of capillary permeability activity from human glioblastoma multiforme (GBM) cell conditioned medium and GBM cyst fluids by anti-VEGPF antibodies demonstrated that VEGPF is secreted by GBM cells and is present in sufficient quantities in vivo to induce vascular permeability. Cloning and sequencing of… CONTINUE READING

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