Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation.

@article{Manku2012ExpressionOT,
  title={Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation.},
  author={Gurpreet Manku and Simon S Wing and Martine Culty},
  journal={Biology of reproduction},
  year={2012},
  volume={87 2},
  pages={
          44
        }
}
The ubiquitin proteasome system (UPS) consists of a cascade of enzymatic reactions leading to the ubiquitination of proteins, with consequent degradation or altered functions of the proteins. Alterations in UPS genes have been associated with male infertility, suggesting the role of UPS in spermatogenesis. In the present study, we questioned whether UPS is involved in extensive remodeling and functional changes occurring during the differentiation of neonatal testicular gonocytes to… CONTINUE READING
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