Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer.

Abstract

PURPOSE Loss of the cell cycle inhibitory protein p27Kip1 in cancer is associated with tumor aggressiveness and poor prognosis in the prostate. The decrease in p27(Kip1) results from increased proteasome dependent degradation, which is mediated by its specific ubiquitin ligase subunits S-phase kinase protein 2 and cyclin dependent kinase subunit 1. S-phase… (More)

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@article{Shapira2006ExpressionOT, title={Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer.}, author={Ma'anit Shapira and Ofer Ben-Izhak and Merav Slotky and Oleg Goldin and Shirly Lahav-Baratz and Dan D. Hershko}, journal={The Journal of urology}, year={2006}, volume={176 5}, pages={2285-9} }