Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.

@article{Deng2002ExpressionOT,
  title={Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.},
  author={Caishu Deng and Alfredo Minguela and R. Z. Inamul Hussain and Amy E. Lovett-Racke and Caius G Radu and E Sally Ward and Michael Karl Racke},
  journal={Journal of immunology},
  year={2002},
  volume={168 9},
  pages={4511-8}
}
Experimental autoimmune encephalomyelitis (EAE) is a CD4 Th1-mediated inflammatory demyelinating disorder of the CNS and a well-established animal model for multiple sclerosis. Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) is a cytosolic tyrosine phosphatase that is involved in regulating the T cell activation cascade from signals initiated through the TCR. To study the role of SHP-1 in EAE pathogenesis, we immunized B10.PL mice heterozygous for deletion of the SHP-1… CONTINUE READING
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