Expression of the two mannose 6-phosphate receptors is spatially and temporally different during mouse embryogenesis.

@article{Matzner1992ExpressionOT,
  title={Expression of the two mannose 6-phosphate receptors is spatially and temporally different during mouse embryogenesis.},
  author={Ulrich Matzner and Kurt von Figura and Regina Pohlmann},
  journal={Development},
  year={1992},
  volume={114 4},
  pages={965-72}
}
Mammalian cells express two mannose 6-phosphate receptors, MPR46 and MPR300, both of which mediate the targeting of lysosomal enzymes to lysosomes. Additionally the receptors mediate the secretion (MPR46) and the endocytosis (MPR300) of lysosomal enzymes and the binding of IGFII (MPR300). We have analyzed the distribution of MPR46 and MPR300 transcripts during mouse embryogenesis by in situ hybridization. Up to day 15.5 of embryonic development we found a non-overlapping distribution of the… CONTINUE READING

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