Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles.

@article{Balasuriya2000ExpressionOT,
  title={Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles.},
  author={Udeni B R Balasuriya and Hans Heidner and Jodi F Hedges and Jacqueline C. Williams and Nancy L. Davis and R. E. Johnston and Nigel James Maclachlan},
  journal={Journal of virology},
  year={2000},
  volume={74 22},
  pages={
          10623-30
        }
}
RNA replicon particles derived from a vaccine strain of Venezuelan equine encephalitis virus (VEE) were used as a vector for expression of the major envelope proteins (G(L) and M) of equine arteritis virus (EAV), both individually and in heterodimer form (G(L)/M). Open reading frame 5 (ORF5) encodes the G(L) protein, which expresses the known neutralizing determinants of EAV (U. B. R. Balasuriya, J. F. Patton, P. V. Rossitto, P. J. Timoney, W. H. McCollum, and N. J. MacLachlan, Virology 232:114… CONTINUE READING
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