Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma

@article{Nowacki2008ExpressionOT,
  title={Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma},
  author={Sophie Nowacki and Matthias Skowron and Andr{\'e} Oberthuer and Alice Fagin and Harald Voth and Benedikt Brors and Frank Westermann and Angelika Eggert and Barbara Hero and Frank Berthold and Martina Fischer},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={3329-3338}
}
Cell adhesion molecule 1 (CADM1) is a putative tumour suppressor gene, which is downregulated in many solid tumours. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with adverse outcome, prompting us to investigate its role in neuroblastoma tumour progression. Oligonucleotide-microarray analysis of 251 neuroblastoma specimens demonstrated that CADM1 downregulation is associated with unfavourable prognostic markers like disseminated stage 4, age >18… CONTINUE READING