Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer.

  title={Expression of the tumor suppressor Kr{\"u}ppel-like factor 4 as a prognostic predictor for colon cancer.},
  author={Nilesh V. Patel and Amr M. Ghaleb and Mandayam O. Nandan and Vincent W. Yang},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={19 10},
BACKGROUND The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous physiologic processes, including proliferation, differentiation, and development. Studies also showed that KLF4 is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether KLF4 is a prognostic indicator for colon cancer. METHODS Levels of KLF4 were measured by immunohistochemical analysis of a tissue microarray containing 367 independent colon cancer sections… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 41 references

The role of Kruppel - like factors in the repro - mming of somatic cells to induced pluripotent stem cells

P ang, R Andrianakos, Y Yang, C Liu, W Lu
Histol topathol • 2009

The pathobiology of Kruppel - like factors in lorectal cancer

BJ oi, YG Cho, JW Song
Curr Colorectal Cancer Rep • 2008

tch inhibits expression of the Kruppel - like factor 4 tumor suppres - in the intestinal epithelium

AM aleb, BB McConnell, MO Nandan
Mol Cancer Res • 2008

Adjuvant treat - nt of colorectal cancer

BM lpin, JA Meyerhardt, HJ Mamon, RJ Mayer
CA Cancer J Clin • 2007

Genetic and epigenetic analysis of KLF 4 gene in gastric cancer

N ng, ZH Liu, F Ding
APMIS • 2007

Haploinsufficiency of ppel - like factor 4 promotes adenomatous polyposis coli depen - nt intestinal tumorigenesis

A mik, Z Lin, A Kumar
Cancer Res • 2007

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