Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer.

  title={Expression of the tumor suppressor Kr{\"u}ppel-like factor 4 as a prognostic predictor for colon cancer.},
  author={Nilesh V. Patel and Amr M. Ghaleb and Mandayam O. Nandan and Vincent W. Yang},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={19 10},
BACKGROUND The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous physiologic processes, including proliferation, differentiation, and development. Studies also showed that KLF4 is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether KLF4 is a prognostic indicator for colon cancer. METHODS Levels of KLF4 were measured by immunohistochemical analysis of a tissue microarray containing 367 independent colon cancer sections… CONTINUE READING