Expression of the transforming growth factor-β gene during growth inhibition following polyamine depletion.

@article{Patel1998ExpressionOT,
  title={Expression of the transforming growth factor-β gene during growth inhibition following polyamine depletion.},
  author={Anami R Patel and Ji Zhou Li and Barbara Bass and Jian-ying Wang},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 2},
  pages={C590-C598}
}
Polyamine depletion and cytokine transforming growth factor-β (TGF-β) inhibit cell proliferation. The current study tests the hypothesis that polyamine depletion results in growth inhibition by altering expression of the TGF-β gene in intestinal epithelial cells. Studies were conducted in the IEC-6 cell line derived from rat small intestinal crypt cells. Cells were grown in DMEM in the presence or absence of α-difluoromethylornithine (DFMO), a specific inhibitor of polyamine biosynthesis, for 6… CONTINUE READING

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