Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo.

@article{Schober1999ExpressionOT,
  title={Expression of the transcription factor lung Kr{\"u}ppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo.},
  author={Sonya L. Schober and Chay T. Kuo and Kimberly S. Schluns and Leo Lefrançois and Jeffrey M. Leiden and Stephen C Jameson},
  journal={Journal of immunology},
  year={1999},
  volume={163 7},
  pages={3662-7}
}
The transcription factor lung Krüppel-like factor (LKLF) is involved in naive T cell survival. Expression of LKLF is rapidly down-regulated upon T cell stimulation, raising the question of whether LKLF is reexpressed after activation, and what factors are required for such reexpression. Furthermore, the expression of LKLF in resting memory cells has not been determined. Here, we use the OT-I TCR transgenic mouse system to address these issues. LKLF was found to be reexpressed following culture… CONTINUE READING

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