Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation

@article{Jenkinson2007ExpressionOT,
  title={Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation},
  author={S. Rhiannon Jenkinson and Andrew M Intlekofer and Guangping Sun and Lionel Feigenbaum and Steven L Reiner and Remy J Bosselut},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={267 - 272}
}
Most T cells belong to either of two lineages defined by the mutually exclusive expression of CD4 and CD8 coreceptors: CD4 T cells are major histocompatibility complex (MHC) II restricted and have helper function, whereas CD8 T cells are MHC I restricted and have cytotoxic function. The divergence between these two lineages occurs during intrathymic selection and is thought to be irreversible in mature T cells. It is, however, unclear whether the CD4-CD8 differentiation of postthymic T cells… CONTINUE READING

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