Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease.

@article{Villa2012ExpressionOT,
  title={Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease.},
  author={Chiara Villa and Elisa Ridolfi and Chiara Fenoglio and Laura Ghezzi and Roberto Vimercati and Francesca Clerici and Alessandra Marcone and Salvatore Gallone and Maria Serpente and Claudia Cantoni and Rossana Bonsi and Sara Cioffi and Stefano F. Cappa and M. Franceschi and Innocenzo Rainero and Claudio Mariani and Elio Scarpini and Daniela Galimberti},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={35 3},
  pages={
          487-94
        }
}
  • Chiara Villa, Elisa Ridolfi, +15 authors Daniela Galimberti
  • Published in
    Journal of Alzheimer's…
    2012
  • Biology, Medicine
  • Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 (specificity protein 1) can regulate the expression of several AD-related proteins, including amyloid-β protein precursor and tau. Sp1 is regulated by oxidative stress, and Sp1 mRNA was found to be upregulated in AD cortex and hippocampus. The distribution of three single nucleotide polymorphisms (SNPs), including rs7300593, rs17695156, and rs12821290, covering 100… CONTINUE READING

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