Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus.

@article{Hendriks1999ExpressionOT,
  title={Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus.},
  author={Rudolf W. Hendriks and Martijn C. Nawijn and James Douglas Engel and H van Doorninck and Frank Grosveld and Alar Karis},
  journal={European journal of immunology},
  year={1999},
  volume={29 6},
  pages={1912-8}
}
GATA-3 is a zinc-finger transcription factor that is essential for both early T cell development and Th2 cell differentiation. To quantify GATA-3 expression during T cell development in vivo in the mouse, the GATA-3 gene was targeted by insertion of a lacZ reporter by homologous recombination in embryonic stem (ES) cells. Although we could detect GATA-3+ cells throughout T cell development in the thymus, the proportions of GATA-3+ cells varied considerably between the distinct differentiation… CONTINUE READING

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