Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer

@article{Span2002ExpressionOT,
  title={Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer},
  author={Paul N Span and Peggy Manders and Joop J. T. M. Heuvel and Chris M. G. Thomas and Remko R. Bosch and Louk V. A. M. Beex and C G J Fred Sweep},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={8506-8509}
}
The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT–PCR in 123 sporadic primary breast cancer samples of patients with a median follow-up time of 62 months. Ets-1 expression levels correlated significantly with VEGF and PAI-1 in the same tissue… CONTINUE READING