• DOI:10.1038/45790
Corpus ID: 4390717

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

@article{Kelz1999ExpressionOT,
  title={Expression of the transcription factor $\Delta$FosB in the brain controls sensitivity to cocaine},
  author={M. Kelz and Jingshan Chen and W. Carlezon and K. Whisler and Lauren Gilden and A. Beckmann and C. Steffen and Ya-Jun Zhang and L. Marotti and D. Self and T. Tkatch and G. Baranauskas and D. Surmeier and R. Neve and R. Duman and M. Picciotto and E. Nestler},
  journal={Nature},
  year={1999},
  volume={401},
  pages={272-276}
}

• M. Kelz, Jingshan Chen, +14 authors E. Nestler
• Published 1999
• Biology, Medicine
• Nature

Acute exposure to cocaine transiently induces several Fos family transcription factors in the nucleus accumbens, a region of the brain that is important for addiction. In contrast, chronic exposure to cocaine does not induce these proteins, but instead causes the persistent expression of highly stable isoforms of ΔFosB. ΔFosB is also induced in the nucleus accumbens by repeated exposure to other drugs of abuse, including amphetamine, morphine, nicotine and phencyclidine. The sustained… Expand