Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.

@article{Roberts2008ExpressionOT,
  title={Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.},
  author={Lori M Roberts and Kathleen Woodford and Mei Juan Zhou and Deborah S Black and Jill E Haggerty and Emily H Tate and Kent K. Grindstaff and Wondwessen Mengesha and Chandrasekaran Raman and Noa Zerangue},
  journal={Endocrinology},
  year={2008},
  volume={149 12},
  pages={6251-61}
}
Thyroid hormones require transport across cell membranes to carry out their biological functions. The importance of transport for thyroid hormone signaling was highlighted by the discovery that inactivating mutations in the human monocarboxylate transporter-8 (MCT8) (SLC16A2) cause severe psychomotor retardation due to thyroid hormone deficiency in the central nervous system. It has been reported that Mct8 expression in the mouse brain is restricted to neurons, leading to the model that organic… CONTINUE READING

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