Expression of the survival of motor neuron (SMN) gene in primary neurons and increase in SMN levels by activation of the N-methyl-D-aspartate glutamate receptor

@article{Andreassi2001ExpressionOT,
  title={Expression of the survival of motor neuron (SMN) gene in primary neurons and increase in SMN levels by activation of the N-methyl-D-aspartate glutamate receptor},
  author={Catia Andreassi and Anna Letizia Patrizi and Umrao R. Monani and A. Burghes and Christina Brahe and Maria Luisa Eboli},
  journal={Neurogenetics},
  year={2001},
  volume={4},
  pages={29-36}
}
Spinal muscular atrophy (SMA) is a common motor neuron degenerative disease caused by mutations of the survival of motor neuron (SMN) gene. The SMN protein is expressed ubiquitously as part of a 300-kilodalton multi-protein complex, incorporating several proteins critically required in pre-mRNA splicing. Although SMN mutations render SMN defective in this role, the specific α-motor neuron degenerative phenotype seen in the disease remains unexplained. During the differentiation process of… CONTINUE READING

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