Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas.

  title={Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas.},
  author={Jan Dimberg and Karin Str{\"o}m and Sture L{\"o}fgren and Niklas Zar and Anders P. Hugander and Andreas Matussek},
  journal={Oncology letters},
  volume={2 3},
Proteases facilitate a number of steps in cancer progression. The serine protease inhibitors (serpins) are a protein superfamily with inhibitory activity against proteases. One of these proteases, serpinA3, appears to have a multifaceted role and is associated with inflammatory reactions, Alzheimer's disease, malignant melanoma and gastric cancer. To gain insight into the potential effect of serpinA3 on colorectal cancer (CRC) we determined whether serpinA3 is altered in colorectal tissue or… CONTINUE READING


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