Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer.

@article{Rvillion2009ExpressionOT,
  title={Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer.},
  author={Françoise R{\'e}villion and Carole Puech and Fanja Rabenoelina and Dany Chalbos and Jean-Philippe Peyrat and Gilles Freiss},
  journal={International journal of cancer},
  year={2009},
  volume={124 3},
  pages={
          638-43
        }
}
Although it is well established that some protein tyrosine kinases have a prognostic value in breast cancer, the involvement of protein tyrosine phosphatases (PTPs) is poorly substantiated for breast tumors. Three of these enzymes (PTP-gamma, LAR, and PTPL1) are already known to be regulated by estrogens or their antagonists in human breast cancer cells. We used a real-time reverse transcriptase polymerase chain reaction method to test the expression levels of PTP-gamma, LAR and its neuronal… CONTINUE READING

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