Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.

@article{Lu2007ExpressionOT,
  title={Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.},
  author={Biao Lu and Peter J. Sims and Therese Wiedmer and Arthur H. Moser and Judy K. Shigenaga and Carl Grunfeld and Kenneth R. Feingold},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1771 9},
  pages={1177-85}
}
Phospholipid scramblase 1 (PLSCR1) is a member of PLSCR gene family that has been implicated in multiple cellular processes including movement of phospholipids, gene regulation, immuno-activation, and cell proliferation/apoptosis. In the present study, we identified PLSCR1 as a positive intracellular acute phase protein that is upregulated by LPS in liver, heart, and adipose tissue, but not skeletal muscle. LPS administration resulted in a marked increase in PLSCR1 mRNA and protein levels in… CONTINUE READING

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