Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer.

@article{Bhren2000ExpressionOT,
  title={Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer.},
  author={J B{\"u}hren and A H Christoph and Rolf Buslei and Steffen Albrecht and Otmar Dieter Wiestler and Torsten Pietsch},
  journal={Journal of neuropathology and experimental neurology},
  year={2000},
  volume={59 3},
  pages={229-40}
}
Medulloblastomas (MBs) are primitive neuroectodermal tumors (PNET) of the cerebellum. They represent the most frequent malignant pediatric brain tumors, but their origin still remains unresolved and controversial. MB cells correspond to different stages of neural development and differentiation as illustrated by their expression of neuronal and glial markers. In the present study, we examined the expression pattern of the common low-affinity neurotrophin receptor p75NTR in a series of 167 MBs… CONTINUE READING
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