Expression of the neurosecretory process in PC12 cells is governed by REST.

  title={Expression of the neurosecretory process in PC12 cells is governed by REST.},
  author={Rosalba D'Alessandro and Andrijana Klajn and Laura Stucchi and P. Podini and Maria Luisa Malosio and Jacopo Meldolesi},
  journal={Journal of neurochemistry},
  volume={105 4},
The neurosecretory process is acquired during differentiation and can be lost en block by differentiated cells. To investigate the role of REST/NRSF, a transcription repressor, in the maintenance of the process we studied two PC12 clones, one wt and one defective, expressing low and high levels of endogenous RE-1 silencing transcription (factor) (REST), respectively. Stable transfection of constructs demonstrated that REST represses 10 genes coding for proteins of neurosecretory vesicles and… CONTINUE READING


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