Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier.

  title={Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier.},
  author={Felix Schlachetzki and Chunni Zhu and William M Pardridge},
  journal={Journal of neurochemistry},
  volume={81 1},
The blood-brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and… CONTINUE READING
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