Expression of the multifunctional Y-box protein, YB-1, in myofibroblasts of the infarcted rat heart.

@article{Kamalov2005ExpressionOT,
  title={Expression of the multifunctional Y-box protein, YB-1, in myofibroblasts of the infarcted rat heart.},
  author={German Kamalov and Balwantkumar R Varma and Li Lu and Yao Sun and Karl T. Weber and Ramareddy V. Guntaka},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={334 1},
  pages={239-44}
}
Intracellular signaling mechanisms regulating the turnover of alpha-SMA-positive myofibroblasts (myoFbs) at the site of myocardial infarction (MI) are poorly understood. Y-Box (YB)-1, a multifunctional protein, may be involved in regulation of proliferation, migration and apoptosis of myoFbs. Our objective was to study the expression of YB-1 in the infarcted rat heart and its localization in myoFbs. On days 3-28 following MI, we monitored YB-1 expression and its colocalization with alpha-SMA… CONTINUE READING