Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts.

  title={Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts.},
  author={Steven Hughes and Julia Magnay and Megan A Foreman and Stephen John Publicover and Jon P. Dobson and Alicia J El Haj},
  journal={Journal of cellular physiology},
  volume={206 3},
TREK-1 is a mechanosensitive member of the two-pore domain potassium channel family (2PK+) that is also sensitive to lipids, free fatty acids (including arachidonic acid), temperature, intracellular pH, and a range of clinically relevant compounds including volatile anaesthetics. TREK-1 is known to be expressed at high levels in excitable tissues, such as the nervous system, the heart and smooth muscle, where it is believed to play a prominent role in controlling resting cell membrane potential… CONTINUE READING


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