Expression of the mRNA encoding truncated PPARα does not correlate with hepatic insensitivity to peroxisome proliferators

@article{Hanselman2001ExpressionOT,
  title={Expression of the mRNA encoding truncated PPARα does not correlate with hepatic insensitivity to peroxisome proliferators},
  author={Jeffrey C. Hanselman and Marsha V. Vartanian and Benjamin P. Koester and Steven A. Gray and Arnold D. Essenburg and Thomas J. Rea and Charles L. Bisgaier and MichaelE. Pape},
  journal={Molecular and Cellular Biochemistry},
  year={2001},
  volume={217},
  pages={91-97}
}
Two alternatively spliced forms of human PPARα mRNA, PPARα1 and PPARα2, have been identified. PPARα1 mRNA gives rise to an active PPARα protein while PPARα2 mRNA gives rise to a form of PPAR which lacks the ligand-binding domain. PPARα2 is unable to activate a peroxisome proliferator response element (PPRE) reporter gene construct in transient transfection assays. Both PPARα1 and PPARα2 mRNA are present in human liver, kidney, testes, heart, small intestine, and smooth muscle. In human liver… CONTINUE READING

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Structure of the mouse peroxisome proliferator activated receptor alpha gene.

Biochemical and biophysical research communications • 1994
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