Expression of the insulin like growth factor-binding protein 3 (IGFBP-3) gene is increased in human renal carcinomas.

@article{Hintz1991ExpressionOT,
  title={Expression of the insulin like growth factor-binding protein 3 (IGFBP-3) gene is increased in human renal carcinomas.},
  author={Raymond L. Hintz and S. De Bock and Arni V. Thorsson and J. Bovens and David R. Powell and Gerhard Jakse and P. E. Petrides},
  journal={The Journal of urology},
  year={1991},
  volume={146 4},
  pages={
          1160-3
        }
}
Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma.
TLDR
Positive correlations were found between the IGFBP3 protein-positive grade in cancerous tissue and the tumor size as well as lymph node metastasis, a larger tumor size and positive lymph nodes metastasis indicating a higher level of IGFBP2 protein- positive grade in OSCC.
Expression of insulin-like growth factor family genes in clear cell renal cell carcinoma
TLDR
Comparing the expression of genes for insulin-like growth factor family in tumours and in tissue of kidneys without cancer found that IGF-1, IGF-2, and IGFR-1 mRNA copy numbers in ccRCC were higher than in the material from the control group.
Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia.
TLDR
Prostatic stromal cell strains isolated from patients with BPH hyperexpress the mRNA for IGF-II and IGF BP-5 while expressing reduced amounts of IGFBP-2 mRNA, the first documentation of altered gene and protein expression in this common disease.
Expression of Insulin-Like Growth Factor-Binding Protein 3 Epidermal Growth Factor Receptor Regulates Aberrant
TLDR
Insulin-like growth factor-binding protein (IGFBP)-3 is identified as the most upregulated gene and it is identified for the first time that IGFBP-3 is an aberrantly regulated gene through the EGFR signaling pathway and it may modulate EGFR effects during carcinogenesis.
Association of insulin-like growth factor binding protein-3 expression with melanoma progression
TLDR
Results strongly suggest that IGFBP-3 expression may be a vital cell motility, migration, and proliferation factor necessary for melanoma metastasis and is an important biomarker in human melanoma.
Epidermal Growth Factor Receptor Regulates Aberrant Expression of Insulin-Like Growth Factor-Binding Protein 3
TLDR
Insulin-like growth factor-binding protein (IGFBP)-3 is identified as the most up-regulated gene and it is identified for the first time that IGFBP-3 is an aberrantly regulated gene through the EGFR signaling pathway and it may modulate EGFR effects during carcinogenesis.
Proteolysis of insulin-like growth factor-binding protein-3 is increased in urine from patients with diabetic nephropathy.
TLDR
Diabetic nephropathy was associated with IGFBP-3 proteolysis in urine, and this is likely to reflect changes in the kidney or urinary tract, resulting in increased local IGF bioavailability, and therefore may contribute to the structural changes of diabetic nephtropathy.
STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma.
TLDR
IGBP-3 influences tumor cell proliferation, migration, and invasion and regulates STAT-1 expression in malignant glioma cells and emerges as a novel prognostic biomarker in glioblastoma.
Characterization of a low molecular mass form of insulin-like growth factor binding protein-3 (17.7 kilodaltons) in urine and serum from healthy children and growth hormone (GH)-deficient patients: relationship with GH therapy.
TLDR
The objectives of this study were to characterize the molecular weight forms of IGFBP-3 in urine and serum of healthy children and adults and in children with GH deficiency (GHD), to quantify the urinary molecular weight Forms of IGF BP-3, and to evaluate the relationship of these forms with GH therapy.
Isolation and functional analysis of differentially expressed genes in human prostate cancer
TLDR
An important role is indicated for the IGF-IR and the IGFBP-3 in cellular homeostasis of prostate carcinoma and provide a further basis for targeting IGF- IR as a potential treatment for prostate cancer as well as a better understanding of the IGF -IR-activated signaling pathways.
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