Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

@article{Pharoah2006ExpressionOT,
  title={Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells},
  author={Daniel S Pharoah and Hemlata Varsani and Richard W Tatham and Katy R Newton and W de Jager and Berent Prakken and Nigel Klein and Lucy R Wedderburn},
  journal={Arthritis Research & Therapy},
  year={2006},
  volume={8},
  pages={R50 - R50}
}
This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production of these three chemokines within the joints of children with juvenile idiopathic arthritis (JIA) of the oligoarticular and polyarticular subtypes. All three of these chemokines are highly expressed at the level of mRNA, with the most significant increase in mRNA levels being demonstrated for CCL5… CONTINUE READING

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