Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats.

@article{Bedo1991ExpressionOT,
  title={Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats.},
  author={Gabriela Bedo and Pilar Santisteban and T Jol{\'i}n and Ana Aranda},
  journal={Molecular endocrinology},
  year={1991},
  volume={5 11},
  pages={1730-9}
}
Diabetes in the rat is associated with poor growth and decreased GH in the pituitary. In this study we have examined whether this reduction reflects an impairment of GH gene expression. Diabetes was induced by the administration of streptozotocin (7 mg/100 g BW), and 18 days later, GH content, GH mRNA, and GH transcription rate were determined. GH mRNA… CONTINUE READING