Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis.

@article{Kaspiris2013ExpressionOT,
  title={Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis.},
  author={Angelos Kaspiris and Constantinos Mikelis and M{\'e}lanie H{\'e}roult and Lubna Khaldi and Theodoros B. Grivas and Ioannis Kouvaras and Spyridon Dangas and Elias D Vasiliadis and Fr{\'e}d{\'e}ric Liot{\'e} and J. M. Courty and Evangelia P Papadimitriou},
  journal={Joint, bone, spine : revue du rhumatisme},
  year={2013},
  volume={80 4},
  pages={407-13}
}
OBJECTIVES Pleiotrophin is a heparin-binding growth factor expressed in embryonic but not mature cartilage, suggesting a role in cartilage development. Elucidation of the molecular changes observed during the remodelling process in osteoarthritis is of paramount importance. This study aimed to investigate serum pleiotrophin levels and expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the cartilage and subchondral bone of osteoarthritis patients. METHODS… CONTINUE READING