Expression of the glucocorticoid receptor alpha and beta isoforms in human nasal mucosa and polyp epithelial cells.

@article{Pujols2003ExpressionOT,
  title={Expression of the glucocorticoid receptor alpha and beta isoforms in human nasal mucosa and polyp epithelial cells.},
  author={Laura Pujols and Joaquim Mullol and Pedro Barredo Benitez and A. Torrego and Antoni Xaubet and Josep de Haro and C{\'e}sar Picado},
  journal={Respiratory medicine},
  year={2003},
  volume={97 1},
  pages={
          90-6
        }
}
The lower sensitivity of the inflamed nasal mucosa to glucocorticoids might be related to an increased expression of the glucocorticoid receptor (GR) beta isoform. We investigated GRalpha and GRbeta mRNA expression in epithelial cells from nasal mucosa and nasal polyps. GRalpha mRNA was at least 1000 times more expressed than GRbeta mRNA in both tissues. GRbeta expression (mean+/-SEM of 10(3) cDNA copies/microg of total RNA) was higher in nasal polyps (1.15+/-0.19; n=27; P<0.01) than in nasal… CONTINUE READING