Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.

@article{Mariottini1999ExpressionOT,
  title={Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.},
  author={Paolo Mariottini and Zahid Hussain Shah and Janne M. Toivonen and Claudia Bagni and Johannes N. Spelbrink and Francesco Amaldi and Howard T. Jacobs},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 45},
  pages={31853-62}
}
The human gene RPMS12 encodes a protein similar to bacterial ribosomal protein S12 and is proposed to represent the human mitochondrial orthologue. RPMS12 reporter gene expression in cultured human cells supports the idea that the gene product is mitochondrial and is localized to the inner membrane. Human cells contain at least four structurally distinct RPMS12 mRNAs that differ in their 5'-untranslated region (5'-UTR) as a result of alternate splicing and of 5' end heterogeneity. All of them… CONTINUE READING