Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development

  title={Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development},
  author={Douglas W. Eib and Tjadine M. Holling and An Zwijsen and Nathalie Dewulf and Egbert de Groot and Adriana J.M van den Eijnden-van Raaij and Danny Huylebroeck and G. J. Martens},
  journal={Mechanisms of Development},
A novel transmembrane protein (designated X7365) containing two follistatin modules and an epidermal growth factor (EGF) domain has been described in the hypothalamic-pituitary axis of Xenopus laevis. We have now cloned the highly conserved mouse orthologue (M7365), and its mRNA was detected in many mesodermal and (neuro)ectodermal tissues in 8.5-day-old mouse embryos. During further development, M7365 mRNA expression became restricted to certain regions in the brain and to ganglia. In the… CONTINUE READING

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