Expression of the epithelial sodium channel (ENaC) in the endometrium – Implications for fertility in a patient with pseudohypoaldosteronism

@article{Boggula2018ExpressionOT,
  title={Expression of the epithelial sodium channel (ENaC) in the endometrium – Implications for fertility in a patient with pseudohypoaldosteronism},
  author={Vijay Raju Boggula and Israel Hanukoglu and Ron Sagiv and Yehoshua Enuka and Aaron Hanukoglu},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2018},
  volume={183},
  pages={137-141}
}
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The epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs and have a central role in regulating ECF volume and blood pressure.
A High Protein Model Alters the Endometrial Transcriptome of Mares
TLDR
Changes in gene expression reveal alterations in endometrial function that could be associated with adverse effects on fertility of mares and are predicted to be related to cell pH, ion homeostasis, changes in epithelial tissue, and solute carriers.
High‐resolution imaging of the actin cytoskeleton and epithelial sodium channel, CFTR, and aquaporin‐9 localization in the vas deferens
TLDR
The localization of all three channels on the apical surface of the columnar epithelial cells provides clear evidence that these channels are involved concurrently in the regulation of fluid and electrolyte balance in the lumen of the vas deferens.
Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns
TLDR
This study highlights the power of high‐resolution confocal microscopy for identifying specific cell types using the simple probe of F‐actin‐binding phalloidin to identify whole kidney sections by confocal microscopic imaging of fluorescent phalloids.
Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
TLDR
The structure of ENaC is described and a combination of precise domain arrangement and complementary hydrogen bonding network defines the subunit arrangement and it is determined that the α subunit has a primary functional module consisting of the finger and GRIP domains.

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