Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals.

@article{Lindl2007ExpressionOT,
  title={Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals.},
  author={Kathryn A. Lindl and Cagla Akay and Yonggang Wang and Michael G. White and Kelly L Jordan-Sciutto},
  journal={Neuropathology and applied neurobiology},
  year={2007},
  volume={33 6},
  pages={658-69}
}
The prevalence of HIV-associated neurocognitive impairment (NCI), which includes HIV-associated dementia (HAD) and minor cognitive and motor disorder (MCMD), has been increasing. HIV-infected and/or activated macrophages/microglia in the brain initiate the neurodegeneration seen in HIV-associated NCI via soluble neurotoxic mediators, including reactive oxygen species, viral proteins and excitotoxins. Neurotoxic factors released by macrophages/microglia injure neurones directly and alter… CONTINUE READING

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