Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis.

@article{Schofield1993ExpressionOT,
  title={Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis.},
  author={J. N. Schofield and Denis Houzelstein and Kay Davies and M. Buckingham and Yvonne H. Edwards},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1993},
  volume={198 4},
  pages={254-64}
}
The utrophin (UTRN) locus is the autosomal homologue of the DMD (Duchenne muscular dystrophy) gene and encodes a protein, utrophin which is thought to be upregulated in the absence of dystrophin. In this study the spatial and temporal expression of the UTRN gene has been examined during mouse embryogenesis and compared with that of the DMD gene. The patterns of expression of these two genes are very different. Whilst DMD is expressed largely in mesodermal derivatives such as cardiac and… CONTINUE READING

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2015 William Allan Award.

American journal of human genetics • 2016

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