Expression of the drug-dependent antigen for quinine-dependent antiplatelet antibodies on GP IIIa but not that on GPIb, IIb or IX on human endothelial cells.


In quinine- and quinidine-induced thrombocytopenic purpura IgG antibodies are known to react in a drug-dependent manner with different combinations of surface glycoproteins (GP) Ib, IIb, IIIa and IX. Because endothelial cells share a number of properties of platelets, including the presence of GP IIIa and GPIb-like proteins, we have compared these two cell… (More)


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