Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.

@article{Lubec1999ExpressionOT,
  title={Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.},
  author={Gert Lubec and Masahiro Nonaka and Kurt Krapfenbauer and markus. gratzer and Nigel J. Cairns and Michael Fountoulakis},
  journal={Journal of neural transmission. Supplementum},
  year={1999},
  volume={57},
  pages={161-77}
}
Deteriorated migration, axonal pathfinding and wiring of the brain is a main neuropathological feature of Down Syndrome (DS). Information on the underlying mechanisms is still limited, although basic functions of a series of growth factors, cell adhesion molecules, guidance factors and chemoattractants for brain histogenesis have been reported. We used proteomics to detect differences in protein expression between control, DS and Alzheimer's disease brains: In five individual brain regions of 9… CONTINUE READING

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