Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.

@article{Figueroa2001ExpressionOT,
  title={Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.},
  author={David J. Figueroa and Richard M Breyer and S K Defoe and Stacia Kargman and Bruce L. Daugherty and K E Waldburger and Quan-hai Liu and Mark Clements and Zhao-shi Zeng and G. Patrick O'Neill and Terence R. Jones and Kevin R Lynch and Christopher P. Austin and J. Fenton Evans},
  journal={American journal of respiratory and critical care medicine},
  year={2001},
  volume={163 1},
  pages={226-33}
}
The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a putative, 7-transmembrane domain, G-protein-coupled receptor, the CysLT1 receptor. The initial molecular characterization of the CysLT1 receptor showed by in situ hybridization, the presence of CysLT1 receptor messenger RNA (mRNA) in human lung smooth-muscle cells and lung… CONTINUE READING
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